Assessment of the Potential Herpes Zoster and Post Herpetic Neuralgia Case Avoidance with Vaccination in the United States

نویسندگان

  • Brandon J Patterson
  • Philip O Buck
  • Justin Carrico
  • Katherine A Hicks
  • Desmond Curran
  • Desiree Van Oorschot
  • John E Pawlowski
  • Bruce Y Lee
  • Barbara P Yawn
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Herpes zoster (Shingles; Zona) is an acute infectious skin disease that is caused by the reactivation of varicella zoster virus (VZV). After the initial infection (chickenpox) or vaccination, the virus remains inactive or latent in the dorsal root ganglia (DRG); when decreasing cell mediated immunity (CMI) occurs, the virus is reactivated from a latent phase to a lytic phase and frequently repl...

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A health economic model for evaluating a vaccine for the prevention of herpes zoster and post-herpetic neuralgia in the UK

BACKGROUND A live-attenuated vaccine aimed at preventing herpes zoster (HZ) and its main complication, post-herpetic neuralgia (PHN) is available in Europe for immunocompetent adults aged 50 years and more. The study objective is to assess the cost effectiveness of a vaccination program for this population in the UK. METHODS A state-transition Markov model has been developed to simulate the n...

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The epidemiology of herpes zoster and post-herpetic neuralgia (PHN) was quantified from a variety of data sources and the potential cost-effectiveness of vaccination assessed. The annual incidence and severity of zoster increases sharply with age, as measured by physician consultation and hospitalisation rates, average length of stay, average proportion of cases developing PHN and the age-speci...

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عنوان ژورنال:

دوره 4  شماره 

صفحات  -

تاریخ انتشار 2017